The differential prognostic implications of PD-L1 expression in the outcomes of Filipinos with EGFR-mutant NSCLC treated with tyrosine kinase inhibitors
نویسندگان
چکیده
Background: The tumor immune microenvironment influences evolution in non-small cell lung cancer (NSCLC). Yet, the prognostic value of programmed death-ligand 1 (PD-L1) epidermal growth factor receptor (EGFR)-mutant NSCLC remains controversial. Additionally, studies Filipinos with EGFR-mutant remain unexplored to this day.
منابع مشابه
PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors
Cancer evades host immune surveillance by using immune checkpoints, which are inhibitory pathways crucial for maintaining self-tolerance 1. Tumor cells express multiple inhibitory ligands, and tumor-infiltrating lymphocytes (TIL) express a variety of inhibitory receptors. Inhibitory receptors cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed death-1 (PD-1) 2 are the most studi...
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ژورنال
عنوان ژورنال: Translational lung cancer research
سال: 2023
ISSN: ['2226-4477', '2218-6751']
DOI: https://doi.org/10.21037/tlcr-23-118